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More than six million people visit the Sistine Chapel each year - making it the third most-visited museum in the world.
This puts a strain on the health of the famous frescos.
So the Vatican Museums rely on modern technology and a small team of experts to monitor the world-renowned frescos.
The BBC's Sara Monetta got exclusive access to witness how Michelangelo’s work is being looked after.
Filmed by Francesco Tosto, produced by Stefano Fasano