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Elsewhere, Miley Cyrus won three prizes for her hit track Flowers, including top radio song, Arctic Monkeys won top rock group, and Coldplay picked up top rock touring artist.
Barbie: The Album took home best soundtrack, girl group Blackpink were named top K-pop touring artist and Jungkook of BTS won best global K-pop song with Seven.
“It is truly an honour, it is very hard to express my gratitude in words,” he said in a pre-recorded video message.
Many of the performances were also pre-recorded, in a break from tradition that allowed for more grandiose staging.
The awards previously took place in May, but moved to November this year to replace the American Music Awards, which are currently on hiatus.