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England's John Ryder was knocked down four times before being stopped in the ninth round by Jaime Munguia on Saturday night.
The 35-year-old, who lost on points against Saul 'Canelo' Alvarez last year, was dropped in the second round and again in the fourth.
Munguia, 27, then floored him twice in the ninth round in Arizona before Ryder's corner stopped the fight.
The win improves Munguia's record to 43 wins without a loss.
His next opponent could be fellow countryman Alvarez, saying after the bout it would be an "honour" to share the ring with him.