Thanksgiving is quickly approaching, with more than 55 million Americans set to travel by road and by sky over the holiday week.

Forecasters are now warning that the usual travel rush could be exacerbated by various weather events across the nation.

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The Transport Safety Administration predicts this year will be the busiest holiday travel year on record, beginning with Thanksgiving.

The agency predicts that 2.7m people will be screened for flights on Wednesday, which is expected to be the busiest flying day of the Thanksgiving holiday stretch.

The easiest day for travel will be on Thanksgiving, when most travelers will be having dinner with their families.

Sunday will be the busiest return day, with the TSA estimating 2.9m travelers will be screened for flights back home.

The FAA is predicting nearly 50,000 flights will take off Wednesday to deliver holiday travelers to their Thanksgiving destinations.

Wednesday will be the peak air travel day, with 49,606 flights scheduled. Tuesday will be the second highest, with 48,403 flights scheduled.

Tuesday may provde a difficult day for air travelers due to a winter storm system moving through the central US into the Midwest and northeast, bringing rain and thunderstorms throughout the region.

Sunday is predicted to be the most popular day for return travelers, with 44,991 flights scheduled.

FAA Administrator Mike Whitaker took to X/Twitter to warn Thanksgiving travelers — who are likely to face possible delays, long lines, and congested airports — to be nice to the flight crews working over the holidays.

“If you’re flying, please be nice to your flight crew. They are there for your safety. The FAA has zero tolerance for unruly behavior,” he said in a post.

Air travelers on Tuesday are most likely to experience disruptions due to a winter storm system moving from the central US across the Midwest and into the northeast.

More than 55 million people are expected to travel at least 50 miles to reach their Thanksgiving destinations between Wednesday and Sunday, and more than 49 million of those travelers will be driving, according to the AAA.

The Transportation Safety Administration expects a significant portion of those drivers will be on the roads Wednesday. Thankfully, much of the inclement weather predicted for the week will be over, but drivers in parts of northern New York and northern New England should be prepared for possibly slick roads due to sleet and freezing rain Tuesday evening.

The National Weather Service reports that most of the precipitation falling east of the Mississippi River over the next two days will be rain.

A major storm system will move across the Midwest and into the northeast on Tuesday, bringing with it thunderstorms and rainfall, which may disrupt flights and cause less than ideal road conditions for motorists traveling for Thanksgiving.

There are some exceptions; the Central Appalachians into portions of the interior northeast may experience sleet and freezing rain on Tuesday morning, and accumulating snows are possible across northern New York state and into northern New England on Tuesday night.

Roads in parts of New York, Vermont and New Hampshire may be slick on Wednesday morning after overnights storms dump a mix of rain and possible snow on the region Tuesday evening.

Snow is expected to arrived in Maine on Wednesday as a storm system begins moving eastward across the US today.

The Midwest and northeast will feel the brunt of the inclement weather on Tuesday, with thunderstorms, snow, and rain likely.

The FAA estimates that 2.6m people will travel through airports each day during the Thanksgiving holiday week.

The administration said that long lines, delays, and congested airports should be expected all week long.

Delays and possible cancellations are likely as thunderstorms, heavy rain, and snow are expected to move from the center of the US through the Midwest and into the northeast on Tuesday and early Wednesday.

The Transportation Security Administration said the 2023 Thanksgiving travel season will be the busiest in US history.

The agency reports the busiest flight days will be Tuesday and Wednesday.

The busiest day for drivers will be Wednesday, according to INRIX, a transportation analytics company.

Drivers are advised to leave home early in the morning or after 6pm to avoid running into the heaviest traffic, INRIX told ABC News.

Inclement weather on Tuesday across the Midwest and northeast may cause delays for air travelers. The storms are expected to die down on Wednesday.